rat pulmonary microvascular endothelial cells (pmvecs) Search Results


rat pulmonary artery endothelial cells (rpaecs)  (Procell Inc)
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Procell Inc rat pulmonary artery endothelial cells (rpaecs)
HIF2α inhibitors improve the activity and expression of mitochondrial complexes I and III, reduce mitochondrial ROS production, and attenuate mitochondrial respiratory depression of PAECs under hypoxia. ( A ) Representative transmission electron microscopy images of <t>endothelial</t> cells from mouse pulmonary arteries with PT2385 intervention (Red arrows indicate swollen mitochondria; scale bars: 500 nm (upper panel), 200 nm (lower panel). ( B ) Summary of data on the activity of mitochondrial complexes I and III in RPAECs. ( C , D ) The representative images of Western blot from mice lung tissues and RPAECs. ( E ) Representative immunofluorescence images and data of MitoSOX in RPAECs (scale bars: 50 μm). ( F ) Summary of data on the intracellular ROS. NC: Normoxia control group; NP: Normoxia combined with PT2385 group; HC: Hypoxia control group; HP: Hypoxia combined with PT2385 group; HCP: Hypoxia combined with PT2385 group (animal model); NIP: PT2385 intervention for 1 week after 4-week hypoxia exposure (animal model); LDH: Lactic dehydrogenase; GLUT1: Glucose transporter 1; ISCU: Iron/sulfur cluster assembly enzyme; MitoSOX: Mitochondrial superoxide; ROS: Reactive oxygen species. The original images of Western Blot can be found in the . In the statistical graph, each point represents the number of experimental animals or repetitions. The data are presented as mean ± SD; ns: No statistical significance; * p < 0.05; ** p < 0.01; *** p < 0.0001.
Rat Pulmonary Artery Endothelial Cells (Rpaecs), supplied by Procell Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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HIF2α inhibitors improve the activity and expression of mitochondrial complexes I and III, reduce mitochondrial ROS production, and attenuate mitochondrial respiratory depression of PAECs under hypoxia. ( A ) Representative transmission electron microscopy images of endothelial cells from mouse pulmonary arteries with PT2385 intervention (Red arrows indicate swollen mitochondria; scale bars: 500 nm (upper panel), 200 nm (lower panel). ( B ) Summary of data on the activity of mitochondrial complexes I and III in RPAECs. ( C , D ) The representative images of Western blot from mice lung tissues and RPAECs. ( E ) Representative immunofluorescence images and data of MitoSOX in RPAECs (scale bars: 50 μm). ( F ) Summary of data on the intracellular ROS. NC: Normoxia control group; NP: Normoxia combined with PT2385 group; HC: Hypoxia control group; HP: Hypoxia combined with PT2385 group; HCP: Hypoxia combined with PT2385 group (animal model); NIP: PT2385 intervention for 1 week after 4-week hypoxia exposure (animal model); LDH: Lactic dehydrogenase; GLUT1: Glucose transporter 1; ISCU: Iron/sulfur cluster assembly enzyme; MitoSOX: Mitochondrial superoxide; ROS: Reactive oxygen species. The original images of Western Blot can be found in the . In the statistical graph, each point represents the number of experimental animals or repetitions. The data are presented as mean ± SD; ns: No statistical significance; * p < 0.05; ** p < 0.01; *** p < 0.0001.

Journal: Biomolecules

Article Title: Iron Replacement Attenuates Hypoxic Pulmonary Hypertension by Remodeling Energy Metabolism via Regulating the HIF2α/Mitochondrial Complex I, III/ROS Axis

doi: 10.3390/biom15050742

Figure Lengend Snippet: HIF2α inhibitors improve the activity and expression of mitochondrial complexes I and III, reduce mitochondrial ROS production, and attenuate mitochondrial respiratory depression of PAECs under hypoxia. ( A ) Representative transmission electron microscopy images of endothelial cells from mouse pulmonary arteries with PT2385 intervention (Red arrows indicate swollen mitochondria; scale bars: 500 nm (upper panel), 200 nm (lower panel). ( B ) Summary of data on the activity of mitochondrial complexes I and III in RPAECs. ( C , D ) The representative images of Western blot from mice lung tissues and RPAECs. ( E ) Representative immunofluorescence images and data of MitoSOX in RPAECs (scale bars: 50 μm). ( F ) Summary of data on the intracellular ROS. NC: Normoxia control group; NP: Normoxia combined with PT2385 group; HC: Hypoxia control group; HP: Hypoxia combined with PT2385 group; HCP: Hypoxia combined with PT2385 group (animal model); NIP: PT2385 intervention for 1 week after 4-week hypoxia exposure (animal model); LDH: Lactic dehydrogenase; GLUT1: Glucose transporter 1; ISCU: Iron/sulfur cluster assembly enzyme; MitoSOX: Mitochondrial superoxide; ROS: Reactive oxygen species. The original images of Western Blot can be found in the . In the statistical graph, each point represents the number of experimental animals or repetitions. The data are presented as mean ± SD; ns: No statistical significance; * p < 0.05; ** p < 0.01; *** p < 0.0001.

Article Snippet: Rat pulmonary artery endothelial cells (RPAECs, CD31 fluorescence identification is reported in ) and human pulmonary artery endothelial cells (HPAECs, the short tandem repeat (STR) assay report is shown in ) were supplied by Wuhan Procell Life Technology Co., Ltd., (Wuhan, China) and Bena Biological Technology Co., Ltd. (Xinyang, China)., respectively, and cultured with endothelial cell medium (ECM, ScienCell Research Laboratories, CA, USA) containing vascular endothelial growth factor at 37 °C with 5% CO 2 .

Techniques: Activity Assay, Expressing, Transmission Assay, Electron Microscopy, Western Blot, Immunofluorescence, Control, Animal Model